Ronald T Raines Selected Research

ranpirnase (Pannon)

11/2011	Arginine residues are more effective than lysine residues in eliciting the cellular uptake of onconase.
7/2009	Onconase cytotoxicity relies on the distribution of its positive charge.
12/2008	Interaction of onconase with the human ribonuclease inhibitor protein.
11/2008	Design and characterization of an HIV-specific ribonuclease zymogen.
1/2008	Ribonucleases as novel chemotherapeutics : the ranpirnase example.
12/2005	Cytotoxicity of bovine seminal ribonuclease: monomer versus dimer.
11/2005	Disruption of shape-complementarity markers to create cytotoxic variants of ribonuclease A.
3/2004	Glycosylation of onconase increases its conformational stability and toxicity for cancer cells.
10/2003	Contribution of active-site residues to the function of onconase, a ribonuclease with antitumoral activity.
2/2003	Ribonuclease inhibitor as an intracellular sentry.

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Ronald T Raines Research Topics

Disease

34	Neoplasms (Cancer) 01/2022 - 03/2002
7	Wounds and Injuries (Trauma) 01/2022 - 08/2012
5	Malignant Mesothelioma 12/2008 - 11/2005
3	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2022 - 01/2017
3	Lung Neoplasms (Lung Cancer) 12/2018 - 09/2010
2	Inflammation (Inflammations) 01/2022 - 09/2014
2	Infections 10/2021 - 10/2020
2	Burns 11/2020 - 11/2019
2	Dehydration (Water Stress) 01/2020 - 01/2019
2	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2019 - 12/2016
2	Melanoma (Melanoma, Malignant) 01/2019 - 12/2018
2	Breast Neoplasms (Breast Cancer) 03/2014 - 02/2012
2	Hypoxia (Hypoxemia) 04/2010 - 05/2003
2	Acute Erythroblastic Leukemia (Erythroleukemia) 04/2007 - 12/2002
2	Skeletal Abnormalities Mandibular Hypoplasia Auditory Canal Atresia Short Stature 08/2006 - 07/2004
1	T-Cell Leukemia (Leukemia, T Cell) 10/2021
1	Proteostasis Deficiencies 01/2019
1	Amyloidosis 01/2017
1	Autistic Disorder (Autism) 12/2016
1	Alzheimer Disease (Alzheimer's Disease) 12/2016
1	Iron Deficiencies 01/2016
1	Adenocarcinoma 07/2015
1	Neoplasm Metastasis (Metastasis) 07/2015
1	Stomach Neoplasms (Stomach Cancer) 03/2014
1	Cardiotoxicity 03/2014
1	Carcinoma (Carcinomatosis) 03/2013

Drug/Important Bio-Agent (IBA)

23	Ribonucleases (Ribonuclease)IBA 01/2022 - 03/2002
15	Pancreatic Ribonuclease (Ribonuclease A)IBA 07/2015 - 03/2002
12	ranpirnase (Pannon)IBA 11/2011 - 03/2002
10	CollagenIBA 01/2022 - 04/2010
9	Proteins (Proteins, Gene)FDA Link 01/2019 - 05/2003
6	EnzymesIBA 01/2017 - 03/2002
4	Peptides (Polypeptides)IBA 01/2022 - 08/2012
3	angiogeninIBA 01/2022 - 01/2017
3	AcidsIBA 01/2020 - 01/2017
3	Polysaccharides (Glycans)IBA 07/2015 - 12/2010
3	Arginine (L-Arginine)FDA Link 11/2011 - 03/2002
2	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 01/2019 - 04/2010
2	Pharmaceutical PreparationsIBA 01/2017 - 03/2014
2	Globo-HIBA 07/2015 - 10/2014
2	AntigensIBA 07/2015 - 10/2014
2	Monoclonal AntibodiesIBA 07/2015 - 10/2014
2	AntibodiesIBA 10/2014 - 03/2014
2	Ethylene Glycol (Monoethylene Glycol)IBA 01/2013 - 07/2004
2	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2013 - 09/2010
2	Oxygen (Dioxygen)IBA 04/2010 - 05/2003
2	placental ribonuclease inhibitorIBA 12/2002 - 03/2002
1	Enzyme Precursors (Zymogens)IBA 10/2021
1	trans-4-hydroxy-L-prolineIBA 01/2020
1	Hydro-Lyases (Dehydratases)IBA 01/2020
1	2-oxoglutarate 3-dioxygenase prolineIBA 01/2019
1	Phosphates (Orthophosphate)IBA 01/2019
1	SolutionsIBA 01/2019
1	AnionsIBA 01/2019
1	FluorineIBA 01/2019
1	Cytotoxins (Cytolysins)IBA 12/2018
1	Protein Kinases (Protein Kinase)IBA 12/2018
1	StilbenesIBA 01/2017
1	Boronic AcidsIBA 01/2017
1	Thyroxine (Levothyroxine)FDA LinkGeneric 01/2017
1	tafamidisIBA 01/2017
1	Substance PIBA 12/2016
1	Cytidine Monophosphate (CMP)IBA 12/2016
1	Amyloid (Amyloid Fibrils)IBA 12/2016
1	A-factor (Streptomyces)IBA 12/2016
1	ethyl protocatechuateIBA 01/2016
1	GalNAc- 1- 3- (Fuc- 1- 2)Gal- 1- 3- GlcNAc- 1- 3- Gal- 1- 4- Glc- PAIBA 07/2015
1	LigandsIBA 07/2015
1	VaccinesIBA 07/2015
1	Phosphatidylinositols (Phosphatidylinositol)IBA 02/2015
1	TensinsIBA 01/2015
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2015
1	LipidsIBA 01/2015
1	stage-specific embryonic antigen-4IBA 10/2014
1	CarbohydratesIBA 10/2014
1	Paclitaxel (Taxol)FDA LinkGeneric 03/2014
1	Trastuzumab (Herceptin)FDA Link 03/2014
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 03/2013
1	fluoro-prolineIBA 08/2012
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 08/2012
1	Coloring Agents (Dyes)IBA 08/2012
1	ProdrugsIBA 02/2012
1	Lysine (L-Lysine)FDA Link 11/2011
1	Cell-Penetrating PeptidesIBA 11/2011
1	Folic Acid (Vitamin M)FDA LinkGeneric 09/2011
1	ElastinIBA 04/2010
1	RNA Polymerase II (RNA Polymerase B)IBA 04/2010
1	Conotoxins (Conotoxin)IBA 04/2010
1	Phosphotransferases (Kinase)IBA 04/2010
1	Cell Surface ReceptorsIBA 07/2009
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2008
1	SilverIBA 08/2006
1	ribonuclease SPLIBA 12/2005
1	Sulfhydryl Compounds (Thiols)IBA 07/2004
1	Glucose (Dextrose)FDA LinkGeneric 05/2003
1	oxalylglycineIBA 05/2003

Therapy/Procedure

2	Immunotherapy 10/2014 - 03/2013
2	Drug Therapy (Chemotherapy) 03/2014 - 02/2003
1	Injections 08/2014
1	Therapeutics 03/2013